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Mutational Signatures & TMB
VCF/MAF → SBS-96 profile + COSMIC v3 signature decomposition.
Live
Parse a VCF or MAF, build the SBS-96 trinucleotide profile in the canonical pyrimidine orientation, and decompose against a COSMIC v3-style reference set (SBS1/3/4/6/7a/13) via multiplicative-update NNLS. Reports cosine similarity, per-signature exposures, and TMB (mut/Mb) for exome or WGS targets.
Canonical SBS-96 plot
Six pyrimidine substitution panels × 16 trinucleotide contexts.
Cosine + exposures
Reconstruction quality and per-signature exposures shown side by side.
TMB built in
Switch between exome (30 Mb) and WGS (3 Gb) targets in one click.
Who it's for
- Cancer signature figures
- Immunotherapy biomarker panels (TMB)
- Mutational aetiology supplements
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